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KMID : 0366319900100020087
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Biochemistry and Molecular Biology News
1990 Volume.10 No. 2 p.87 ~ p.91
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Abstract
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Interactions between lymphocytes are an essential of the immune response both in vivo and in vitro. T cell-B cell cooperation in the antibody response to immunization with antigens was the first type of cellular interactions to be studied and it still remains the most widely used model system. The production of antibodies by B lymphocytes in response to most protein antigens depends on the helper function of T lymphocytes. Helper T cells provide both specific: and non-specific help for B cells or for the subsets of T cells involved in cytotoxic or supressor reactions. Despite the fact that T cell-B cell cooreperation in antibody response has been recognized for over two decades, the fine details of the mechanism are not fully understood. The principles in cellular interactions between immunocompetant cells are one of critical areas of immunolgy to understand the two dominant topics of immunological science, immune recognition and immune regulation.
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KEYWORD
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